Skip to main content
. 2020 Nov 24;10(69):42457–42492. doi: 10.1039/d0ra07204d

Comparison of the space-time yield (STY) for three dipeptides synthesised by reactive extrusion, ball-milling and solution phase synthesis199.

Dipeptide STY (g per cm3 per day−1)
Reactive extrusion Ball-milling Solution-phasea
Boc-Trp-Gly-OMe 48.0 2.6 1.8
Boc-Trp-Phe-OMe 37.0 2.1 1.1
Boc-Asp(OBn)-Phe-OMe 471.2 2.2 4.9 (0.2)b
a

Reaction performed with Et3N as base and DMF as solvent.

b

Reaction performed with NaHCO3 as base and acetone as solvent.