Solvent free synthesis of di-, tri-, tetra- and pentapeptides by Jain and co-workers using microwave irradiation200.
| Peptide | Yielda (%) | Purityb (%) |
|---|---|---|
| Ser(Bn)-Ile | 99 | 96 |
| Pro-Met-Ile | 70 | 98 |
| Ala-Thr(Bn)-Phe-Ile | 60 | 97 |
| Arg-Lys(Z)-Asp(Bn)-Val-Tyr(Bn) | 55 | 95 |
| Carnosine | 78 | 95 |
| Aspartame | 92 | 98 |
| Thyrotropin releasing hormone | 82 | 94 |
| Thymopentin | 53 | 97 |
| Leu-enkephalin | 62 | 99 |
a
Reaction conditions: coupling: AA (1.2 equiv.), DIPEA (3 equiv.), DIC (1.2 equiv.), HONB (1.2 equiv.), 60 °C, 15 min, 40 W, deprotection: 6 N HCl, 25 °C, 15 min.
b
Purity was determined by RP-HPLC analysis.