Solubility of Fmoc-protected amino acids and reagents at 0.2 M concentration in different solvents reported by Lopez et al.13a.
| Solvent/reagent | Fmoc-Gln(Trt)-OH | Fmoc-Gly-OH | Oxyma | DIC | DIU |
|---|---|---|---|---|---|
| Anisoleb | I | I | S | S | I |
| DMIE | S | S | S | S | S |
| NEPc | S | S | S | S | S |
| DMPUc | S | S | S | S | S |
| THFb | S | S | S | S | PS |
| NBP | S | S | S | S | S |
| 2-MeTHF | S | S | S | S | PS |
| Propyl acetate | S | S | S | S | I |
| TMUc | S | S | S | S | S |
| DEC | I | I | S | S | I |
| Toluenec | I | I | I | S | I |
| DMFc | S | PS | S | S | PS |
| NMPc | S | S | S | S | S |
| EtOAc | S | I | S | S | I |
a
The indicated solvent (10 mL) was added to 2 mmol of each reagent. All mixtures were stirred at the same speed and temperature (22–23 °C) for 10 min. Subsequent visual inspection was reported as soluble (S), partially soluble (PS), or insoluble (I).
b
Poorly characterised solvent.
c
Environmentally problematic solvent.