Table 3.
SpO2, HR, MBP and Application of Vasoactive Drugs During Anesthesia (n = 64 in Each Group)
| Remimazolam Group | Propofol Group | Difference (95% CI) | P value | |
|---|---|---|---|---|
| SpO2 (%) | ||||
| Baseline | 100.0(1.0) | 100.0(1.0) | 0.0(0.0 to 0.0) | 0.973 |
| 1 min after induction | 100.0(0.0) | 100.0(0.0) | 0.0(0.0 to 0.0) | 0.440 |
| 1 min after intubation | 100.0(0.0) | 100.0(0.0) | 0.0(0.0 to 0.0) | 0.156 |
| At the beginning of surgery | 100.0(0.0) | 100.0(0.0) | 0.0(0.0 to 0.0) | 0.081 |
| HR (beats/min) | ||||
| Baseline | 77.7±14.7 | 74.7±12.3 | 2.9(−1.8 to 7.7) | 0.225 |
| 1 min after induction | 75.5±13.0 | 65.7±11.5 | 9.8(5.5 to 14.1) | 0.000* |
| 1 min after intubation | 74.0(15.8) | 66.0(21.8) | −9.0(−14.0 to −4.0) | 0.001* |
| At the beginning of surgery | 61.0(19.3) | 58.5(11.8) | −2.0(−6.0 to 2.0) | 0.203 |
| MBP (mmHg) | ||||
| Baseline | 108.8±12.6 | 106.0±12.3 | 2.8(−1.6 to 7.1) | 0.210 |
| 1 min after induction | 94.4±12.9 | 87.4±11.9 | 7.0(2.7 to 11.4) | 0.002* |
| 1 min after intubation | 93.0(17.0) | 93.0(30.8) | −2.0(−7.0 to 5.0) | 0.642 |
| At the beginning of surgery | 86.5(17.0) | 86.0(24.0) | −1.0(−5.0 to 4.0) | 0.800 |
| Application of vasoactive drugs | 18.0(28.1%) | 36.0(56.3%) | 28.1%(11.0% to 43.0%) | 0.001* |
Notes: Data for HR and MBP at baseline and 1 min after induction were presented as mean ± standard deviation and the difference (95% CI) was the mean difference and its 95% CI. Data for application of vasoactive drugs were presented as number (percentage) and the difference (95% CI) was the proportion difference and its 95% CI. Other data were presented as median (interquartile range), and the difference (95% CI) was the median of all pairwise differences between observations in the two groups, rather than the difference between the group medians. *p < 0.05, compared with propofol group.
Abbreviations: SpO2, pulse oxygen saturation; HR, heart rate; MBP, mean blood pressure; CI, confidence interval.