Table 3.

Histology Scoring Data of Anal Fissure Model

Histology Scoring
Sl No	Groups	Erosion and Ulcer Formation	Inflammatory Cell Infiltration
1	G1: control	0±0	0±0
2	G2: pathological control 1 (25 g)	1.00±0.32	1.00±0.32
3	G3: pathological control 2 (50 g)	1.80±0.20*	1.60±0.24*
4	G4: pathological control 3 (100 g)	2.60±0.24***	2.00±0.32**

Notes: The values are expressed as mean ± SEM (n=5). The mean values of the groups were compared using one-way ANOVA followed by Kruskal–Wallis test and Dunnett’s posttest. ***p < 0.001, **p < 0.01 and *p < 0.05 compared with G1: control. Histology severity score: NAD: 0 (no abnormality detected); minimal: 1 (very small amount of changes ≤10%); mild: 2 (lesion is easily identified but limited severity 11–30%); moderate: 3 (lesion is predominant 31–70%); severe: 4 (the degree of changes is 71–100% or great enough in intensity or extent to expect significant tissue or organ dysfunction).