Table 2.
60 Key Targets of Ba Zhen Tang for Delaying Skin Photoaging
| Gene Names | Protein Names | Degree |
|---|---|---|
| AKT1 | RAC-alpha serine/threonine-protein kinase | 53 |
| TP53 | Cellular tumor antigen p53 | 50 |
| MAPK3 | Mitogen-activated protein kinase 3 | 48 |
| IL6 | Interleukin-6 | 48 |
| TNF | Tumor necrosis factor | 47 |
| MAPK1 | Mitogen-activated protein kinase 1 | 45 |
| PTGS2 | Prostaglandin G/H synthase 2 | 45 |
| MYC | Myc proto-oncogene protein | 45 |
| CASP3 | Caspase-3 | 44 |
| JUN | Transcription factor AP-1 | 44 |
| MAPK8 | Mitogen-activated protein kinase 8 | 44 |
| VEGFA | Vascular endothelial growth factor A | 42 |
| MMP9 | Matrix metalloproteinase-9 | 41 |
| CAT | Catalase | 40 |
| ESR1 | Estrogen receptor | 40 |
| IL1B | Interleukin-1 beta | 39 |
| EGF | Pro-epidermal growth factor | 39 |
| EGFR | Epidermal growth factor receptor | 39 |
| MAPK14 | Mitogen-activated protein kinase 14 | 38 |
| FOS | Proto-oncogene c-Fos | 38 |
| MMP2 | 72 kDa type IV collagenase | 37 |
| PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase | 37 |
| SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | 36 |
| PPARG | Peroxisome proliferator-activated receptor gamma | 35 |
| CASP8 | Caspase-8 | 35 |
| HIF1A | Hypoxia-inducible factor 1-alpha | 35 |
| BCL2L1 | Bcl-2-like protein 1 | 34 |
| CASP9 | Caspase-9 | 33 |
| TGFB1 | Transforming growth factor beta-1 proprotein | 31 |
| SOD1 | Superoxide dismutase | 29 |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 | 29 |
| NFKBIA | NF-kappa-B inhibitor alpha | 28 |
| MMP3 | Stromelysin-1 | 27 |
| MMP1 | Interstitial collagenase | 27 |
| NOS2 | Nitric oxide synthase | 26 |
| MAPK10 | Mitogen-activated protein kinase 10 | 25 |
| NFE2L2 | Nuclear factor erythroid 2-related factor 2 | 24 |
| ESR2 | Estrogen receptor beta | 20 |
| CCNA2 | Cyclin-A2 | 19 |
| PPARA | Peroxisome proliferator-activated receptor alpha | 18 |
| GSR | Glutathione reductase | 18 |
| COL1A1 | Collagen alpha-1(I) chain | 18 |
| BAX | Apoptosis regulator | 17 |
| FASN | Fatty acid synthase | 16 |
| IL1A | Interleukin-1 alpha | 16 |
| ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | 15 |
| RXRA | Retinoic acid receptor RXR-alpha | 14 |
| CTSD | Cathepsin D | 13 |
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | 13 |
| ODC1 | Ornithine decarboxylase | 12 |
| BAD | Bcl2-associated agonist of cell death | 12 |
| HSF1 | Heat shock factor protein 1 | 11 |
| COL3A1 | Collagen alpha-1(III) chain | 9 |
| PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 7 |
| RXRB | Retinoic acid receptor RXR-beta | 7 |
| CYP1B1 | Cytochrome P450 1B1 | 7 |
| ACACA | Acetyl-CoA carboxylase 1 | 5 |
| XDH | Xanthine dehydrogenase/oxidase | 5 |
| PPARD | Peroxisome proliferator-activated receptor delta | 5 |
| SULT1E1 | Sulfotransferase 1E1 | 2 |