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. 2022 Apr 18;13:842232. doi: 10.3389/fmicb.2022.842232

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Copyright © 2022 Garanina, Hamza, Stott-Marshall, Martynova, Markelova, Davidyuk, Shakirova, Kaushal, Baranwal, Khaertynova, Rizvanov, Foster and Khaiboullina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reactivity of COVID-19 serum to SARS-CoV-2 peptides depending on age of patients. Patients were divided into young (<45 years old) and old (≥45 years old) groups. Antibody reactivity was analyzed using ELISA. Peptides were adsorbed on a 384-well plate and probed with serum samples. Only reactivity to peptides which significantly differed from that in corresponding age control is presented. (A) Age groups dependent difference to SARS-CoV-2 peptides reactivity in COVID-19 serum. Asterisks indicate statistically significant differences between reactivity to SARS-CoV-2 peptides depending on age of the patient (p < 0.05, Kruskal-Wallis test with Benjamini-Hochberg adjustment). (B) Age based distribution of reactivity to SARS-CoV-2 peptides in COVID-19 patient serum. Colored lines – linear regression of OD450 value.