Information of the top 10 important descriptors' and other descriptors' obvious correlations with log Papp values.

Importance ranking	Descriptor name	Correlation	Description
1	maxHssNH	−0.35	Maximum atom-type H E-state: –NH–
2	maxHbint6	−0.51	Maximum E-State descriptors of strength for potential hydrogen bonds of path length 6
3	EE_Dt	−0.42	Estrada-like index from detour matrix
4	hmax	−0.3	Maximum H E-state
5	ATSC1s	0.42	Centered Broto-Moreau autocorrelation − lag 1/weighted by I-state
6	AAS1i	−0.25	Average Broto-Moreau autocorrelation − lag 1/weighted by first ionization potential
7	SHsOH	−0.35	Sum of atom-type H E-State: –OH
8	maxHBint2	−0.39	Maximum E-state descriptors of strength for potential hydrogen bonds of path length 2
9	ETA_Epslion_5	−0.02	A measure of electronegative atom count
10	maxHBint7	−0.49	Maximum E-state descriptors of strength for potential hydrogen bonds of path length 7
12	nHBa	−0.56	Count of E-states for (strong) hydrogen bond acceptors