Physicochemical properties comparison of an aza-DKP and its DKP equivalent.
| |||
| Compound | Aza-DKP 5 | DKP 4 | |
| Solubility (mM) | 16.5 ± 0.6 | 1.0 ± 0.1 | |
| Log D | 1.1 ± 0.1 | 1.4 ± 0.1 | |
| Stability (%) | PBS (25 °C, 24 h) | >98 | >98 |
| Plasma (37 °C, 6 h) | >98 | >98 | |
| Microsomes (37 °C, 30 min) | 83 ± 3 | 51 ± 1 | |