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. 2020 Dec 7;10(71):43358–43370. doi: 10.1039/d0ra09457a

Physicochemical properties comparison of an aza-DKP and its DKP equivalent.

graphic file with name d0ra09457a-u5.jpg
Compound Aza-DKP 5 DKP 4
Solubility (mM) 16.5 ± 0.6 1.0 ± 0.1
Log D 1.1 ± 0.1 1.4 ± 0.1
Stability (%) PBS (25 °C, 24 h) >98 >98
Plasma (37 °C, 6 h) >98 >98
Microsomes (37 °C, 30 min) 83 ± 3 51 ± 1