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. 2022 Apr 30;14:17588359221096219. doi: 10.1177/17588359221096219

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© The Author(s), 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — (a) The cancer-immunity cycle displaying all pivotal steps to generate an effective tumor-specific immune response. (b) Impaired cancer-immunity cycle due to missing antigens. (c) Impaired cancer-immunity cycle due to impaired T-cell priming in the local lymph node – no matching T-cell receptors. (d) Impaired cancer-immunity cycle due to impaired T-cell priming in the local lymph node – immune checkpoint signaling. (e) Impaired cancer-immunity cycle due to systemic factors inhibiting tumor-specific T-cells in the blood stream. (f) Impaired cancer-immunity cycle due to immune checkpoint signaling in the local tumor microenvironment.