Table 1.
Patients’ demographic and maternal baseline characteristics.
| No treatment (n = 513) |
Pre. plus IVIg (n = 151) |
Pre. (n = 172) |
IVIg (n = 105) |
p value | ||||
|---|---|---|---|---|---|---|---|---|
| All groups | IVIg versus pre | Pre. plus IVIg versus IVIg | Pre. plus IVIg versus pre. | |||||
| Maternal age (years), mean (SD) | 29.47 (4.63) | 29.31 (4.56) | 29.22 (4.50) | 29.20 (4.36) | 0.956 | 0.979 | 0.851 | 0.849 |
| BMI (kg/m2), mean (SD) | 23.40 (3.63) | 23.27 (3.02) | 23.59 (3.41) | 23.51 (2.90) | 0.706 | 0.841 | 0.589 | 0.403 |
| Primiparity, n (%) | 301 (58.7) | 122 (80.8) | 100 (58.1) | 74 (70.5) | <0.001 | 0.036 | 0.088 | <0.001 |
| Age at ITP diagnosis, mean (SD) | 24.89 (5.30) | 24.59 (6.75) | 24.08 (5.59) | 24.67 (6.33) | 0.623 | 0.408 | 0.916 | 0.424 |
| Maternal pretreatment platelet count (×109/l), mean (SD) | NA | 13.51 (9.99) | 20.99 (10.96) | 16.57 (10.10) | <0.001 | 0.001 | 0.020 | <0.001 |
| Gestational age at platelet nadir (wk), median (range) | 33.5 (8, 40) | 28.0 (7, 41) | 32.0 (8, 40) | 30.5 (9, 40) | <0.001 | 0.087 | 0.032 | <0.001 |
| Operative vaginal delivery (n/N) (%) | 22/302 (7.3) | 8/114 (7.0) | 9/125 (7.2) | 5/78 (6.4) | 0.941 | 0.833 | 0.873 | 0.957 |
| Cesarean section, n (%) | 211 (41.1) | 37 (24.5) | 47 (27.3) | 27 (25.7) | <0.001 | 0.781 | 0.839 | 0.589 |
| Bleeding score (%) | <0.001 | 0.050 | 0.019 | <0.001 | ||||
| 0 | 454 (88.5) | 102 (67.5) | 146 (84.9) | 80 (76.2) | ||||
| 1 | 59 (11.5) | 46 (30.5) | 23 (13.4) | 23 (21.9) | ||||
| 2 | 0 (0.0) | 2 (1.3) | 2 (1.2) | 0 (0.0) | ||||
| 3 | 0 (0.0) | 1 (0.7) | 1 (0.6) | 2 (1.9) | ||||
| 4 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||
BMI, body mass index; ITP, immune thrombocytopenia; IVIg, intravenous immunoglobulin; NA, not applicable; pre., prednisone; SD, standard deviation.