TABLE 3.

Susceptibilities of P. aeruginosa PAO1 and its isogenic mutants to penem antibiotics^a

Strain	Phenotypeb			MIC (μg/ml) of:
	AmpC	MexAB	OmpF	Faropenem	Ritipenem	AMA3176	Sulopenem	Sch29482	Sch34343
PAO1	+	+	−	512	128	128	32	256	128
PAO1/pKMF010	+	+	+	32	8	8	0.25	8	8
KG2225	+	−	−	32	64	8	4	4	4
KG2225/pKMF010	+	−	+	2	4	1	0.125	1	2
KG2504	−	+	−	256	32	64	16	128	64
KG2504/pKMF010	−	+	+	32	4	16	0.25	8	4
KG2505	−	−	−	1	2	0.5	0.125	1	1
KG2505/pKMF010	−	−	+	0.5	2	0.5	0.06	0.5	0.5
OCR1	+	++	−	4,096	512	1,024	128	2,048	1,024

^aMICs were determined in experiments with L agar containing 1 mM IPTG. The presence of pKMF012 (vector control) alone in the tested strains did not change the susceptibility to any agent in this table. 

^b+, wild-type level; −, nonexpression; ++, overexpression.