Cytotoxicity of N2-methyl indazole derivatives on five cell lines.
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R2 | R1 = H (IC50a (μM)) | R1 = CH3 (IC50a (μM)) | ||||||||||
| Cpd | A549 | SK-HEP-1 | SNU-638 | MDA-MB-231 | HCT116 | Cpd | A549 | SK-HEP-1 | SNU-638 | MDA-MB-231 | HCT116 | |
|
38 | 38.9 ± 13.2 | >100 | 30.4 ± 27.0 | 68.3 ± 27.3 | 33.4 ± 11.7 | 45 | >100 | >100 | >100 | >100 | >100 |
|
22 | 58.7 ± 23.9 | >100 | >100 | 20.6 ± 1.7 | 2.5 ± 1.6 | 23 | >100 | >100 | >100 | >100 | >100 |
|
39 | 1.8 ± 1.4 | >100 | 2.8 ± 1.3 | 1.7 ± 1.1 | >100 | 46 | >100 | >100 | >100 | >100 | >100 |
|
40 | 37.4 ± 10.2 | >100 | >100 | >100 | >100 | 47 | 37.0 ± 22.7 | 32.7 ± 11.2 | 33.0 ± 17.5 | >100 | 26.1 ± 13.8 |
|
41 | >100 | >100 | >100 | >100 | 49.7 ± 3.6 | 48 | >100 | >100 | >100 | >100 | >100 |
|
42 | >100 | >100 | >100 | >100 | >100 | 49 | >100 | >100 | >100 | 19.4 ± 17.0 | 19.1 ± 13.5 |
|
43 | >100 | >100 | 63.3 ± 13.8 | >100 | >100 | 50 | 19.4 ± 20.6 | 37.3 ± 6.3 | 10.8 ± 11.2 | 8.0 ± 1.7 | 13.8 ± 6.5 |
|
44 | >100 | >100 | >100 | >100 | >100 | 51 | >100 | >100 | >100 | 61.3 ± 32.3 | 12.7 ± 8.5 |
| Etoposide | 0.27 ± 0.1 | 0.30 ± 0.1 | 0.61 ± 0.2 | 7.35 ± 2.3 | 1.27 ± 0.8 | |||||||
a
IC50: the concentration (μM) of compounds that produces a 50% reduction cell growth. All the data were calculated from the experiments conducted in triplicate and repeated at least three times. Data represent mean ± SD.