Fig. 2.

Validation and semi-quantification of selected metabolites, and the metabolic network map of the differential metabolites. The RPA of (A) adenosine, (B) taurine, (C) β-GPA, (D) L-isoleucine and (E) myo-Inositol, in reference to the retention time of reference standards and the peak area of internal standards. (F) The metabolic network map of the differential metabolites. The red dots represent that metabolites in the model group were up-regulated compared with those in the Rb1 group and the down-regulated metabolites were represented by green dots. Results were presented as mean ± SD. ^#P < 0.05, ^##P < 0.01 vs. the sham group; ∗∗P < 0.01 vs. the model group, n = 8.