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(a) Scheme of the preclinical therapeutic device using a bifocal acoustic hologram. Microbubbles were injected intravenously (IV) for the FUS delivery, while the gadolinium was injected intraperitoneally (IP) post-FUS delivery for the MRI procedure. (b) Photograph of the hologram manufactured by stereo-lithographic 3D-printing techniques using translucent resin, and geometrical parameters of the study. The thickness profile of the hologram is given by the function h(x0, y0).
