Representative hematoxylin–eosin (H&E) tissue slides.
Patients with (A) MSS/pMMR and (B) MSI/dMMR tumors from all cohorts and corresponding detection maps based on the tile-wise detection of the deep learning classifier.
dMMR, mismatch repair deficiency; DACHS, Darmkrebs: Chancen der Verhütung durch Screening; MECC, Molecular Epidemiology of Colorectal Cancer; MSI, microsatellite instability; MSS, microsatellite stable; NLCS, Netherlands Cohort Study; TCGA, The Cancer Genome Atlas; pMMR, proficient mismatch repair; QUASAR, Quick and Simple and Reliable; UMM, University Medical Center Mannheim.