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. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: Exp Cell Res. 2022 Mar 31;415(2):113134. doi: 10.1016/j.yexcr.2022.113134

Fig. 2. Signaling to generate F-actin foci is necessary for myoblast fusion.

Fig. 2.

Schematic showing molecular players and cellular pathways that result in a F-actin focus, which push membranes close to 10 nm and begin to establish a fusion synapse. Serum response factor (Srf) increases Actin transcription. Phosphatidylserine (PS) is normally located on the inner leaflet of the plasma membrane. Movement of PS to the outer leaflet provides a signal for PS receptors including Bai1 and Stabilin-2, which activate signaling to generate F-actin through the Arp2/3 complex. Localization of actin polymerization is proposed to be regulated by binding of PI(4,5)P2 to Arp2/3.