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. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: Exp Cell Res. 2022 Mar 31;415(2):113134. doi: 10.1016/j.yexcr.2022.113134

Fig. 3. Membrane remodeling to drive myoblast fusion.

Fig. 3.

The independent activities of Myomaker and Myomerger culminate in myoblast fusion. Possible function for Myomaker is that it generates domains of negative curvature, promoting closer membrane apposition and outer leaflet membrane mixing (hemifusion). F-actin may provide mechanical support for these domains of negative curvature. Myomerger has two helical regions in its ectodomain. The helix proximal to the transmembrane domain responds to phosphatidylserine exposure to insert in membranes, causing membrane stress and promoting positive curvature, leading to pore formation and completion of the fusion reaction.