Table 3.
. Summary of targeting drug delivery system based on MSNs.
| Targeting receptor | Targeting ligand | Target cell type | Refs. |
|---|---|---|---|
| EGFR | Epidermal growth factor | HuH-7 | (Mickler et al., 2012) |
| α-Folate receptor | Folic acid | MDA-MB 435 MDA-MB-231 PANC-1, MiaPaCa-2 MCF-7, Hela Hela |
(Wang et al., 2010) (Tao et al., 2010) (Sarkar et al., 2016) (Lu et al., 2012) (Prasad et al., 2016) |
| α-Folate receptor Mitochondria membrane |
Folic acid Triphenylphosphine |
LnCAP | (López et al., 2017) |
| Mannose receptor | Mannose | MCF-7, HCT-116, MDA-MB-231 | (Brevet et al., 2009) |
| Galactose receptor | Galactose | Hela, A549 | (Niemelä et al., 2015) |
| Mucin-1 glycoprotein | Mucin-1 antibody | MMT, Mtag | (Dréau et al., 2016) |
| CD105 protein | TRC105 antibody | 4T1 | (Wang et al., 2013) |
| CD44 protein | Hyaluronic Acid | MCF-7, MDA-MB-321, 4T1 | (Kang et al., 2019) |
| αvβ3 integrins | cRGD | MDA-MB 435 | (Ferris et al., 2011) |
| Transferrin receptor | Transferrin | HepG2 | (Montalvo-Quiros et al., 2019) |