Table 4.

The 30 most important features as determined by a RF model without PCA, using only hand-crafted image and clinical features (i.e. without deep learning features). The sum of importances of all features equals 1.

Feature name	Feature importance value
img_LAB_Amean	0.034231
img_LAB_Lstd	0.033047
img_RGB_Rstd	0.032891
Pre_Alb	0.027744
img_HSV_Vstd	0.023306
img_RGB_Gmean	0.021559
img_HSV_Sstd	0.018536
img_HSV_Smean	0.017932
img_RGB_Gstd	0.017794
img_glrlm_SRHGE	0.017419
PTB	0.017041
Infection	0.017015
img_LAB_Bstd	0.016309
img_RGB_Bmean	0.015348
BSA	0.014811
img_glrlm_LGRE	0.012993
img_gabor_amp_std_4	0.012843
WndWdth	0.012599
img_glrlm_RLV	0.01215
img_ngtdm_Complexity	0.011454
img_glszm_GLV	0.011221
img_HSV_Hmean	0.011206
img_glszm_LGZE	0.01048
img_glcm_Correlation	0.010403
Age	0.010116
img_gabor_amp_mean_4	0.010031
img_RGB_Bstd	0.009844
img_glcm_Variance	0.00958
UTSAStage	0.009379
img_glrlm_LRLGE	0.009364

Std: Standard deviation. SRHGE: Short-run high gray-level run emphasis Amp: Amplitude. Std: Standard deviation. LAB: CIELAB color space. RGB: RGB color space. HSV: HSV color space. GLRLM: Gray-Level Run Length Matrix. SRHGE: Short-run high gray-level run emphasis. PTB: Probe to bone, BSA: Body surface area. LGRE: Low gray-level run emphasis. GLV: Gray-level variance. RLV: Run level variance. NGTDM: Neighborhood Gray Tone Difference Matrix. GLSZM: Gray-level size-zone matrix. LGZE: Low gray-level zone emphasis. LRE: Long run emphasis. LZE: Level zone emphasis. LGRE: Low gray-level run emphasis. GLCM: Gray-level co-occurrence matrix. ZSV: Zone-size variance. ZP: Zone percentage. SZHGE: Small zone high gray-level emphasis. LRLGE: Long-run low gray-level run emphasis.