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Quinolone-induced DNA cleavage by gyrase
| Compound | Relative amt of drug required to induce 50% maximal DNA cleavage for mutanta
|
||
|---|---|---|---|
| Ala83 | Ala87 | Ala83 Ala87 | |
| Ciprofloxacin | 3.6 ± 0.2 | 3.9 ± 1.6 | 8.9 ± 1.8 |
| PD0163449 | 1.4 ± 0 | 3.1 ± 0.4 | 4.3 ± 1.4 |
| Norfloxacin | 4.8 ± 1.0 | 4.4 ± 0.8 | 20.5 ± 1.6 |
Calculated as the amount of drug required to induce 50% maximal cleavage for the mutant divided by the amount required to induce 50% maximal cleavage for the WT.
