Table 1. Curating Compounds Based on Activity against S. aureus vs E. coli.
pathogen | compound 1 | compound 2 | compound 1887 | |
---|---|---|---|---|
S. aureus | pMIC ≥ 5 | pMIC ≥ 5 | ... | pMIC ≥ 5 |
E. coli | pMIC ≥ 5 | pMIC < 5 | pMIC ≥ 5 | |
final labela | 1 | 0 | 1 |
Compounds that are active against both pathogens above a threshold MIC are labeled “1” (GN-permeable), and compounds that are active against S. aureus but inactive against E. coli are labeled “0” (GN-impermeable).