Fig. 2.

Spinal cord lesions across vertebral levels. (A) Violin plots show spinal cord (SC) lesion volumes across groups (HC, healthy controls; CIS, clinically isolated syndrome; RRMS, relapsing-remitting multiple sclerosis; PMS, progressive multiple sclerosis). Note the logarithmic scale of the y axis. Statistical significance is marked by asterisks (p < 0.05, *; p < 0.01, **; p < 0.001, ***). (B) Mean volumes and standard error of SC lesions on the y axis are plotted across vertebral levels on the x axis (C, cervical; T, thoracic; L, lumbar) separately for HC (no lesions), CIS, RRMS, and PMS. Level-wise statistical significance is indicated by non-overlapping confidence intervals. (C) Frequency plots show the percentage of patients with at least one lesion across SC levels, separately for HC, CIS, RRMS, and PMS.