Fig. 5.

Association of spinal cord lesions and atrophy with disability (EDSS) across vertebral levels. (A) Level-wise simple non-parametric correlations of scores at the Expanded Disability Status Scale (EDSS) and spinal cord lesion volumes are plotted across vertebral levels (C, cervical; T, thoracic; L, lumbar), separately for patients with clinically isolated syndrome or relapsing-remitting multiple sclerosis (CIS / RRMS), progressive MS (PMS), and all patients together. Of each group, color-coded correlation measures with their 95% confidence intervals (colored areas) are displayed. For visibility, these values were smoothed (default function of ggplot2). Level-wise statistical significance is indicated by non-overlapping of confidence intervals with zero. (B) Analogous plots derived from level-wise simple correlations of EDSS and spinal cord volumes are displayed.