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. Author manuscript; available in PMC: 2022 May 2.
Published in final edited form as: Biochemistry. 2021 Jul 22;60(30):2331–2340. doi: 10.1021/acs.biochem.1c00420

Figure 1.

Figure 1.

Combining theoretical and experimental approaches to determine how motions are correlated in proteins. Theoretical models include those based on sequence (represented by an MSA) and structure (represented by an ENM). Among experimental methods, total X-ray scattering from crystals stands out for its ability to measure high-resolution structure and correlated motions simultaneously. Shown on the right is a set of residues that was predicted to coevolve in DHFR (PDB: 1RX2) by statistical coupling analysis41 (shown in blue).