Fig. 4. Effect of chromium malate (5.0, 10.0 and 20.0 μg Cr per mL, low, middle and high dose groups) on Irs-1 (A), p-Irs-1 (B), PPARγ (C), PI3K (D) and p38-MAPK (E) expression and p-Irs-1/Irs-1 (F) level in 3T3-L1 cells with insulin resistance. Chromium trichloride (20.0 μg Cr per mL) and chromium picolinate (20.0 μg Cr per mL) were used as a positive control. Each value was presented as means ± SD (n = 10). ^aSignificantly different from normal group (p < 0.05); ^bsignificantly different from model group (p < 0.05); ^csignificantly different from chromium trichloride group (p < 0.05); ^dsignificantly different from chromium picolinate group (p < 0.05).