Table 3.
Comparison of serum BDNF level and clinical parameters before and after treatment with duloxetine
| Value | Before treatment | After treatment | Statistic |
|---|---|---|---|
| FIQR | 53.6 (19.0) | 36.4 (22.9) | P < 0.01 |
| BDI-II | 17.0 (10.0) | 13.9 (11.3) | P = 0.01 |
| PSD | 14.8 (4.6) | 8.4 (3.3) | P < 0.01 |
| Pain VAS | 7.1 (2.0) | 4.4 (3.0) | P < 0.01 |
| Serum BDNF (pg/ml) | 5293.5 (2676.3) | 3608.2 (2584.6) | P < 0.01* |
Values are mean (standard deviation), * This value is based on a linear mixed model adjusted for BDI-II, FIQR and pain VAS. FIQR: Revised Fibromyalgia Impact Questionnaire, BDI-II: Beck Depression Inventory-II, PSD: polysymptomatic distress scale, Pain VAS: Pain visual Analog scale. P value < 0.05 is statistically significant