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. 2022 Apr 28;154(9):e202012613. doi: 10.1085/jgp.202012613

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© 2022 Guarina et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 7. — SR Ca²⁺ release is the largest source of beat-to-beat [Ca²⁺]_i variability in adult rabbit ventricular myocytes. (a and b) Representative averaged [Ca²⁺]_i transient and associated signal variance of adult rabbit ventricular myocytes and the distribution of peak amplitude [Ca²⁺]_i variance (nM²) of adult ventricular myocytes under control conditions (a) and in the presence of the SERCA inhibitor thapsigargin (1 μM; b). (c) Population data for the amplitude of [Ca²⁺]_i variance during EC coupling (control, n = 23 cells; thapsigargin, n = 20 cells; ****, P < 0.0001).