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. 2022 Apr 28;221(6):e202109065. doi: 10.1083/jcb.202109065

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© 2022 Leguay et al.

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Figure 8. — Model for ERM activation and cell rounding at mitosis entry. The Cdk1/Cyclin B complex promotes both Ect2 phosphorylation (Matthews et al., 2012) and interphase microtubule disassembly (McHedlishvili et al., 2018), leading to GEF-H1 release and activation. GEF-H1 and Ect2 activate RhoA that in turn activates SLK and ROCK kinases. While ROCK kinases take charge of the phosphorylation of myosin II to generate actomyosin forces, SLK activates ERMs that integrate the actomyosin forces to the plasma membrane. This integrated signaling network promotes cell rounding at mitotic entry.