Fig. 2.

Preexisting type 1 diabetes mellitus prevents posttraumatic osteoarthritis in C57BL/6J male mice. (A) Schematic representation of the experimental design. (B) Histological evaluation of uninjured and injured control and diabetic mice at 6 weeks post‐injury using Safranin O (red = cartilage) and Fast Green (green = surrounding tissue) (5× and 20× magnification; scale bars = 100 and 10 μm). PTOA severity was quantified using the Osteoarthritis Research Society International (OARSI) scoring system. (C) Osteophyte imaging using μCT and osteophyte volume at 6 weeks post‐injury. Bar graph values are average ± standard error; n = 5 per group. Statistical analysis performed by t test. *p < 0.05; **p < 0.001.