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. Author manuscript; available in PMC: 2023 Mar 15.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2021 Nov 11;112(4):1055–1062. doi: 10.1016/j.ijrobp.2021.11.008

Fig. 3.

Fig. 3.

Predicted treatment outcomes with different combination sequences. (A) Schematic providing the key for 3B: negative values on the time axis indicate RT started before immune checkpoint inhibitors, positive values indicate after immune checkpoint inhibitors. (B) Response rates as a function of radiation therapy start time for nonirradiated tumor. Radiation therapy is delivered as 8 Gy × 3 to 90% of the tumor burden, that is, this case corresponds to the 90% irradiated tumor fraction case in Figure 1. Abbreviations: CR = complete response; ICI = immune checkpoint inhibitor; PR = partial response; RT = radiation therapy; SD = stable disease.