Table 2.
Characteristics of modeled rotavirus vaccines.
| Vaccine | Volume per FIC* (cm3) |
Volume per dose (cm3) |
Doses per vial |
Doses per child |
Price per dose (2020 $USD) |
Storage temperature |
Open vial policy |
|---|---|---|---|---|---|---|---|
| ROTASIIL RV5 (single-dose, liquid) | 59.5 | 19.8 | 1 | 3 | 1.55 | 2-8C | NA |
| ROTASIIL RV5, (single-dose)^ | 52.8 | 17.6 | 1 | 3 | 1.55 | 2-8C | NA |
| Rotavac 5D (single-dose) | 48 | 16 | 1 | 3 | 1.58 | 2-8C | NA |
| Rotarix (RV1) | 34.2 | 17.1 | 1 | 2 | 2.2 | 2-8C | NA |
| ROTASIIL RV5 (two-dose)^ | 31.5 | 10.5 | 2 | 3 | 0.95 | 2-8C | Discard after six hours |
| Rotarix (RV1, MMP) | 23.6 | 11.8 | 1 | 2 | 2.2 | 2-8C | NA |
| Rotavac 5D (five-dose) | 12.6 | 4.2 | 5 | 3 | 1.14 | 2-8C | Discard after six hours / 28 days** |
| Rotavac (five-dose) | 12.6 | 4.2 | 5 | 3 | 0.85 | −20C, 2-8C | Discard after six hours / 28 days** |
| Rotavac (ten-dose) | 9.6 | 3.2 | 10 | 3 | 0.85 | −20C, 2-8C | Discard after six hours / 28 days** |
*
FIC: Fully-immunized child.
^
Requires reconstitution.
**
Five-dose and ten-dose rotavirus vaccine simulations included a sensitivity analysis allowing these vaccines to remain open for 28 days.