Synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives (IVa–m) in the presence of Fe3O4@ nano-cellulose/Cu(ii) under solvent-free condition at 80 °Ca appear here with headings as appropriate.
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Ent. | R | Prod. | Time (min) | Yieldb (%) | M. P. | Ref. | |
Found | Report | ||||||
1 | H– | IVa | 45 | 84 | 178–180 | 177–179 | 17 |
2 | 4-NO2– | IVb | 30 | 97 | 171–173 | 170–172 | 22 |
3 | 4-Cl– | IVc | 30 | 95 | 87–89 | 86–88 | 21 |
4 | 4-Br– | IVd | 30 | 97 | 110–114 | 110–114 | 16 |
5 | 4-OH– | IVe | 60 | 82 | 210–212 | 210–212 | 22 |
6 | 2-NO2– | IVf | 45 | 88 | 122–125 | 122–125 | 23 |
7 | 2-Cl– | IVg | 40 | 87 | 124–126 | 125–127 | 17 |
8 | 2-EtO– | IVh | 60 | 75 | 171–175 | 171–175 | 23 |
9 | 3-NO2– | IVi | 35 | 93 | 222–224 | 222–224 | 21 |
10 | 3-OH– | IVj | 65 | 79 | 260–263 | 260–263 | 23 |
11 | 2,4-(Cl)2– | IVk | 45 | 85 | 133–135 | 133–135 | 17 |
12 | 2,4-(MeO)2– | IVl | 75 | 74 | 164–166 | 164–166 | 23 |
13 | 3,4-(OH)2– | IVm | 70 | 71 | 225–227 | 225–227 | 23 |
I (mmol) : II (mmol) : III (mmol) : Fe3O4@ nano-cellulose/Cu(ii) (g) is equal to 1 : 1 : 1 : 0.03.
Isolated yield.