Table 3.

Adjusted pairwise differences in the AHI and the risk of severe OSA between weight-change groups at the end of the study.

Reference Group	Weight Change Group	AHI (events/h)			Severe OSA
		MDa	95% CIa	P a	RRa	95% CIa	P a
WS/GG	< 5%WLG	−5.83	−14.8 to 3.12	.504	0.77	0.37 to 1.59	.478
	5%–10%WLG	−15.6	−23.9 to −7.38	.006	0.45	0.23 to 0.87	.018
	≥ 10%WLG	−29.8	−38.1 to −21.4	< .001	0.32	0.17 to 0.64	.001
< 5%WLG	5%–10%WLG	−9.79	−18.7 to −0.86	.023	0.59	0.30 to 1.14	.115
	≥ 10%WLG	−23.9	−32.9 to −15.0	< .001	0.42	0.22 to 0.82	.012
5%–10%WLG	≥ 10%WLG	−14.1	−22.3 to −5.96	.010	0.72	0.40 to 1.29	.268

Results are presented as adjusted mean differences for the AHI and adjusted relative risk for severe OSA at the 6-month follow-up, with their corresponding 95% confidence intervals, as derived from the analysis of covariance and generalized linear models, respectively. Analyses were performed in the intention-to-treat population (n = 180). ^aAdjusted for age, sex, baseline levels of the dependent variable, and continuous positive airway pressure use (hours/day). The Bonferroni correction was applied to adjust for multiple pairwise comparisons. P values < .050 indicate statistically significant results. AHI = apnea-hypopnea index, CI = confidence interval, MD = mean difference, OSA = obstructive sleep apnea, RR = relative risk, WLG = weight-loss group, WS/GG = weight-stable/gain group.