Fig. 4. Lack of miR-25-3p suppressed HIF-1α-induced tumorigenesis via regulation of IL-6/STAT3 signaling pathway. Tumor volumes of C57/BL6 (A and C) and E0771 mice (B) injected with NC, miR-25-3p-in, HIF-1α, or HIF-1α + miR-25-3p-in-transfected E0771 cells were calculated every week. (D and E) The protein expressions of IL-6, p-STAT3, and STAT3 in tumor tissues of C57/BL6 mice were detected by western-blot assay.
