Table 2.

Whole-Brain Group Results for Alcohol vs. Beverage Contrast.

Comparison	Voxels	Region	X	Y	Z	Peak Z	p-value
Main Effect of Group
	1628	Bilateral niPFC	−4	60	20	4.52	<0.001
	1079	Bilateral Cingulate	−2	−22	34	4.31	<0.001
	908	L Caudate	−10	18	12	4.09	<0.001
	407	R Midbrain/VTA	6	−24	−10	3.64	0.02
	356	R Superior Frontal Gyrus	12	12	62	3.46	0.04
	347	L Superior Frontal Gyrus	−14	18	60	3.83	0.04
VAR > VAR + NTX
	711	R Thalamus	20	−30	−2	3.72	<0.001
	345	L Caudate	−14	8	14	3.53	0.04
VAR + NTX > VAR
	N/A
VAR > PLAC
	N/A
PLAC > VAR
	N/A
VAR + NTX > PLAC
	N/A
PLAC > VAR + NTX
	525	R Parahippocampus, Hippocampus, Thalamus	18	−30	−6	4.2	0.004
Age +
	890	L Superior Parietal Lobule	−30	−54	70	4.24	<0.001
Age −
	N/A

VAR = varenicline; VAR + NTX = varenicline and naltrexone; PLAC = placebo; L = left; R = right; Coordinates are in Montreal Neurological Institute (MNI) space.