Table 1.
Participant Characteristics.
| Control (n = 12) | Methamphetamine (n = 11) | Group Comparison p-value | |
|---|---|---|---|
| Sex (# of women / # of men) | 5 / 7 | 2 / 9 | 0.240 |
| Age (years) a | 33.8 ± 7.48 | 38.3 ± 9.31 | 0.219 |
| Education (years) a | 13.5 ± 2.10 | 13.4 ± 3.01 | 0.499 |
| Race (% of participants) | |||
| Caucasian | 2 | 7 | |
| African American | 8 | 3 | |
| Mixed | 1 | 1 | |
| Other | 1 | 0 | |
| Ethnicity (# of participants) | |||
| Hispanic/Latino | 2 | 5 | |
| Not Hispanic/Latino | 10 | v6 | |
| Other | 0 | 0 | |
| Striatal dopamine D2-type receptor binding (BPnd) a,b | 28.8 ± 2.16 | 23.4 ± 6.6 | 0.0135* |
| Self-Reports of Mood and Emotional States a | |||
| Depressive symptoms c | 1.17 ± 1.53 | 13.73 ± 9.19 | 0.0001**** |
| Trait Anxiety d | 28.58 ± 8.80 | 42.64 ± 10.14 | 0.002** |
| Difficulty in Emotion R egulation e | 54.25 ± 15.96 | 74.91 ± 19.83 | 0.012* |
| Substance Usea | |||
| Methamphetamine (days in past 30) | 0 ± 0 | 24.18 ± 8.13 | N/A |
| Average grams per day | 0 ± 0 | 0.62 ± 0.31 | N/A |
| Days abstinent at [11C]DAA scan | 35.18 ± 57.57 | N/A | |
| Cannabis (days in past 30) | 8.09 ± 12.25 | 4.25 ± 8.70 | 0.393 |
| Alcohol (days in past 30) | 3.92 ± 5.07 | 5.6 ± 6.88 | 0.619 |
| Tobacco (all participants daily smokers) | |||
| Cigarettes per day a | 9.00 ± 7.37 | 7.36 ± 6.52 | 0.580 |
| Nicotine Dependence f | 3.33 ± 2.77 | 2.27 ± 2.65 | 0.180 |
a
Mean ± standard deviation.
b
Determined using [18F]fallypride and positron emission tomography (see methods).
c
Beck Depression Inventory (Beck and Beamesderfer, 1974).
d
Y-2 form of the State-Trait Anxiety Inventory (Spielberger and Gorsuch, 1983).
e
Difficulties in Emotional Regulation Scale, total score (Gratz and Roemer, 2004).
f
Fagerström Test for Nicotine Dependence (Fagerström, 1978; Heatherton et al., 1991).