Figure 3.

(A) OncoPrint describing alterations in previously identified driver genes and in genes involved in signaling processes frequently affected in our cohort. (B) KDM5A expression in cases with (≥2) and without (<2) multiple copy gains. (C) homologous recombination deficiency (HRD) score, single base substitution signatures (SBS3 and SBS8), structural variant signatures (SV signature 3 and 5), fraction of deletions with microhomology, and the aggregate HRDetect score in the cohort. (D) Hierarchical clustering of ACC tumors with transcriptome profiles (biopsy site is indicated for each case).