Fig. 4. Neutralization of heparan sulfate (HS) by heparin-binding copolymer (HBC) in rat plasma. Neutralization was monitored in vitro by measuring activated partial thromboplastin time (aPTT, A), prothrombin time (PT, B), anti-factor Xa (anti-fXa) activity (C), and anti-factor IIa (anti-fXa) activity (D). Results are shown as median values with lower and upper limits. Dotted lines indicate normal values for coagulation parameters of rat plasma.