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. Author manuscript; available in PMC: 2023 Apr 12.
Published in final edited form as: Immunity. 2022 Apr 4;55(4):639–655.e7. doi: 10.1016/j.immuni.2022.03.005

Figure 5. STAT binding motifs at Tbx21-CNS-12 are dispensable for T-bet induction during cNK cell and ILC1 development.

Figure 5.

(A and B) T-bet protein amounts in cNK cells and ILC1s from Tbx21+/+, Tbx215M/5M and Tbx21−/− mice were measured (A). Total cNK and ILC1 cell number in livers from Tbx21+/+ (n=13) and Tbx215M/5M (n=14) was calculated (B). Mean ± SD.

(C) Purified cNK cells and ILC1s from Tbx21+/+ (n=4) and Tbx215M/5M (n=3) mice were stimulated with IL-12 and IL-18 for 5 hours in the presence of monensin. The percentage of IFN-γ-producing cells was calculated. Mean ± SD.

Data are representative of two (A-C) independent experiments. See also Figure S4 and S5.