FIGURE 4.

Effects of MT‐7117 on the coat colour darkening of Ay/a mice. MT‐7117 and NDP‐αMSH were administered for 6 days and, then, the coat in the dorsal area was shaved and the colour of the newly grown coat was assessed as yellow or black. ^## p < 0.01 versus vehicle by Fisher's exact test, **p < 0.01 versus vehicle by Fisher's exact test with multiplicity adjusted using fixed sequence procedure. (a) Representative image of each group on day 6 (above) and the number of mice with the emergent coat colour determined as yellow or black (below). (b) Representative image of Fontana‐Masson staining of dorsal skin in the vehicle‐treated group on day 6. The pigment in the hair root was brownish yellow. (c) Similar image to (b) from the MT‐7117 group treated at 3 mg/kg. The pigment in the hair root was black