Skip to main content
. 2022 Apr 20;16(4):e0010359. doi: 10.1371/journal.pntd.0010359

Fig 2. Detection of ZIKV RNA in chorionic villi of placentas perfused with ZIKV.

Fig 2

ZIKV RNA was detected with ISH in formalin fixed, paraffin embedded tissue of perfused placentas. Chromogenic staining for cytokeratin-7 (cyto-7) and CD163 was performed in sequential slides to detect trophoblasts and Hofbauer cells, respectively. A: Staining for ZIKV RNA, trophoblasts and Hofbauer cells in a placenta that was perfused for 40 minutes with ZIKVBPL+DENV nAbs. B: Staining for ZIKV RNA, trophoblasts and Hofbauer cells in a placenta that was perfused for 120 minutes with ZIKVBPL+flavivirus naïve serum. C: Staining for ZIKV RNA in a placenta that was obtained directly after birth and was not perfused. Arrows indicate positive signal for ZIKV RNA.