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. Author manuscript; available in PMC: 2023 Apr 25.
Published in final edited form as: Int J Pharm. 2022 Mar 8;618:121650. doi: 10.1016/j.ijpharm.2022.121650

Table 2.

Pharmacokinetic parameters of blood COHb levels following p.o. administration of AC-CO-306 and free CO-306.

Compound Vehicle Dose (mg/kg) COHb AUC (%·h) COHb Cmax COHb Tmax
BW-AC-306 3% CMC 100 4.6 6.0% 20 min
50 1.3 3.1% 20 min
BW-CO-306 DMA/PEG400 100 2.9 5.1% 10 min

COHb AUC: area under the curve for blood COHb level subtracting the pre-administration baseline from time zero to the last sampling time point; COHb Cmax: peak carboxyhemoglobin level; COHb Tmax: time at which peak COHb level was reached; Results are presented as the mean ± SD (n ≥ 3).