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Pharmacokinetic parameters of saccharin following p.o. administration of BW-AC-306 and BW-CO-306.
| Saccharin origin | Dose (mg/kg) | Tmax (min) | t1/2 (h) | AUC0–2h (μM·h) | Cmax (μM) |
|---|---|---|---|---|---|
| BW-AC-306 | 100 | 20 | 2.98 | 58.4 | 39.2 |
| BW-CO-306 | 100 | 10 | 1.14 | 76.2 | 50.5 |
t1/2: terminal half-life; AUC0–2h: area under the plasma drug concentration curve from time zero to 2 h; Results are presented as the mean ± SD (n ≥ 3).
