Fig. 2.

Overview of the accumulation of DaMiV infections in the healthy infant gut. (A) The accumulation over time of the number of unique infections by DaMiVs (on a species level) detected, colored per infant. Black crosses indicate infections for which an enteric sign (diarrhea or vomiting) was detected, within 7 d after the start of that infection. Note that for the calculation of the accumulation of DaMiV infections, reads attributed to live attenuated rotavirus vaccines were disregarded. (B) The number of accumulated infections before and after the start of specific events of interest (day-care entrance, breast milk, formula milk, fruit, vegetables, the first half-year) is shown in the boxplots and statistically compared using the paired Wilcoxon test. Nonsignificant results (P > 0.05) are indicated (ns). The number of accumulated infections before and after day-care entrance was found to be significantly different (paired Wilcoxon test, n = 8 + 8, R² = 0.892, P = 0.014). The body of the boxplots represents the first and third quartiles of the distribution and the median line. (C) The number of accumulated infections per day (i.e., infection rate) before and after the start of specific events of interest (day-care entrance, breast milk, formula milk, fruit, vegetables, the first half-year) is shown in the boxplots and statistically compared using the paired Wilcoxon test. The infection rate before and after day-care entrance was found to be significantly different (paired Wilcoxon test, n = 8 + 8, R² = 0.841, P = 0.016). The body of the boxplots represents the first and third quartiles of the distribution and the median line.