Fig. 1.

Aerosolized saline induces abrupt retrograde movement of microdisks in CF airways. Maximal intensity projection of a dynamic CT scan from a CF pig in coronal reconstruction, showing microdisk deposition and movement in the airways. (A) Basal conditions. Black circles indicate a cluster of nonmoving microdisks; red circles indicate a cluster of moving microdisks. (B) After IV methacholine and intratracheal saline. Black circles indicates a cluster of nonmoving microdisks; red and blue circles indicate clusters of moving microdisks that are transported ∼2 cm from their original location in ∼2.5 min before they abruptly (∼8.5 s) recoiled backward in a single frame (asterisk). Real time in minutes and frame number are indicated for each panel. Images were inverted to enhance contrast between microdisks and airway tree shadow. (Scale bar = 1 cm.).