Table 1.
Baseline Characteristics According to Quartile of Total DHT
| All participants | Dihydrotestosterone (DHT) by quartile | P value | ||||
|---|---|---|---|---|---|---|
| Characteristic | N=1128 | Q1 N=302 (0.01-0.29)* | Q2 N=269 (0.30-0.41)* | Q3 N=277 (0.42-0.55)* | Q4 N=280 (0.56-1.87)* | |
| Age, years | 76.5 (5.1) | 76.9 ± 5.5 | 76.5 ± 5.0 | 76.1 ± 4.9 | 76.6 ± 5.1 | 0.31 |
| Weight, kg | 80.0 (12.4) | 84.4 ± 13.6 | 81.2 ± 11.3 | 78.9 ± 11.8 | 75.1 ± 10.5 | <0.01 |
| Height, cm | 172.9 (6.5) | 172.9 ± 7.0 | 173.1 ± 5.8 | 173.1 ± 6.5 | 172.5 ± 6.6 | 0.48 |
| Body Mass Index, kg/m2 | 26.6 (3.6) | 28.1 ± 3.9 | 27.0 ±3.4 | 26.2 ± 3.4 | 25.1 ± 3.1 | <0.01 |
| Body Surface Area, m2 | 1.95 (0.17) | 2.01 (0.18) | 1.97 (0.15) | 1.94 (0.17) | 1.89 (0.15) | <0.01 |
| eGFRcys, mL/min/1.73m2 | 73.1 (17.1) | 71.1 ± 17.2 | 71.8 ± 17.9 | 74.2 ± 15.5 | 75.2 ±17.6 | <0.01 |
| Sitting**, hours/day | 14.6 (3.6) | 14.8 ±3.6 | 14.5 ± 3.6 | 14.5 ± 3.7 | 14.6 ± 3.5 | 0.62 |
| Black race | 14.7% | 15.9% | 13.8% | 13.0% | 16.1% | 0.66 |
| Education (≥ 12th grade) | 51.8% | 48.3% | 52.6% | 52.7% | 53.8% | 0.56 |
| Current Smoker | 11.8% | 10.8% | 12.3% | 11.6% | 12.7% | 0.91 |
| Diabetes | 9.9% | 16.9% | 8.6% | 6.9% | 6.8% | <0.01 |
| Hypertension | 52.6% | 63.6% | 55.0% | 45.8% | 45.0% | <0.01 |
| Levothyroxine use | 4.9% | 4.6% | 5.6% | 2.9% | 6.5% | 0.24 |
| Oral steroid use | 2.8% | 6.0% | 3.7% | 1.1% | 0.0% | <0.01 |
| Finasteride use | 2.4% | 8.6% | 0.4% | 0.0% | 0.0% | <0.01 |
| Testosterone (ng/dl) | 381.7 (181.1) | 225.6 (140.6) | 344.3 (94.9) | 421 (100.7) | 546.5 (189.4) | <0.01 |
| Dihydrotestosterone (ng/ml) | 0.33 (0.23) | 0.19 (0.09) | 0.36 (0.03) | 0.48 (0.04) | 0.75 (0.19) | -- |
*
DHT quartile ranges, units ng/ml
**
Sitting=Number of hours spent sitting or lying down each day
Continuous variables are shown as mean (± standard deviation)
Categorical variables are shown as percent