Figure 6.

Meta-analysis of the effects of remdesivir vs control on mortality in Solidarity and other trials, by respiratory support at study entry

High-flow and low-flow oxygen were not recorded separately at entry into Solidarity. Ventilation includes non-invasive ventilation. Full details of these meta-analyses are given in the appendix (p 53). Solidarity data are from figure 2 and table 2, and other data are published (supplementary table 10).⁷ O − E=observed minus expected number of deaths. RR=rate ratio. *If V is the variance of the log-rank statistic O − E then RR is obtained by taking log_e RR to be (O − E) / V with normal variance 1 / V. Summation of (O − E) and of V yields the stratified total (providing the inverse-variance-weighted average of the separate log_e RR values).