Kinetic parameters of CDD hydrolysis in plasma and buffer (pH 7.4) at 37 °C.

System	k 1 (min−1)	k 2 (min−1)	t 1/2 (min)	t max (min)
Rat plasma	7.61 ± 0.50	15.0 ± 0.4	0.0914 ± 0.0062	0.0921 ± 0.0033
Dog plasma	8.97 ± 1.26 (×10−2)	4.91 ± 0.60 (×10−2)	7.82 ± 1.02	15.0 ± 1.6
Human plasma	0.147 ± 0.027	0.220 ± 0.007	4.85 ± 0.95	5.58 ± 0.57
Phosphate buffer (pH 7.4)	1.43 ± 0.30 (×10−3)	—	499.1 ± 107.6	—