Inhibition of CDD hydrolysis in rat, dog, and human plasma by esterase inhibitors.

Inhibitors	Target	Concentration	% inhibitiona
			Rat	Dog	Human
BNPP	CES	0.1 mM	83.0 ± 8.9	16.6 ± 8.2	<10%
		1 mM	97.0 ± 7.7	63.6 ± 1.8	42.2 ± 6.7
BW284c51	AChE	10 μM	<10%	<10%	<10%
		100 μM	<10%	<10%	<10%
Iso-OMPA	BChE	0.1 mM	99.5 ± 11.2	16.9 ± 7.1	<10%
		1 mM	108.3 ± 5.2	17.6 ± 6.7	<10%
Eserine	ChE	10 μM	<10%	<10%	<10%
		100 μM	<10%	<10%	<10%
TLCK	Serine hydrolase	0.1 mM	<10%	<10%	<10%
		1 mM	<10%	17.0 ± 10.3	<10%
PMSF	Serine hydrolase	0.1 mM	<10%	<10%	<10%
		1 mM	96.0 ± 9.2	29.6 ± 5.3	<10%
Pefabloc® SC	Serine hydrolase	0.1 mM	19.4 ± 2.1	<10%	<10%
		1 mM	99.8 ± 7.9	25.8 ± 3.1	<10%
DTNB	Arylesterase	0.1 mM	<10%	<10%	<10%
		1 mM	<10%	47.8 ± 0.83	52.0 ± 1.5
EDTA	PON	5 mM	<10%	<10%	<10%
		10 mM	<10%	<10%	<10%
EGTA	PON	5 mM	<10%	17.3 ± 6.1	23.2 ± 11.4
		10 mM	<10%	19.9 ± 8.0	26.5 ± 3.6
NaF	Non-specific	5 mM	<10%	<10%	<10%
		10 mM	24.4 ± 7.1	<10%	<10%

^a% inhibition < 10% is considered as no inhibition.